The Systems Biology of COVID-19 and the SARS-CoV-2 virus. The class will build a foundation that includes the emergence of complexity, simple biological subsystems, their reductionist and equivalent toy and organ-chip models, and the measurements required to specify model architecture and parameters. Applications to biology, physiology, medicine, chemical and biological defense, pharmacology, drug discovery, and toxicology. UGrad: PHYS 240 01 and BME 290B; Grad: PHYS 326 and BME 395C.
Tuesday, March 13, 2012
Asgn_19_Class_24_Article_17_2012_03_14
Read Article 17: Lahav,G, Rosenfeld,N, Sigal,A, Geva-Zatorsky,N, Levine,AJ, Elowitz,MB, Alon,U. Dynamics of the P53-Mdm2 Feedback Loop in Individual Cells, Nat.Genet., 36, 147-150, 2004. This is the first paper in the series. Try to figure out what was learned between 2004 and 2010. Post a PCRC.
Asgn_18_Class_24_Article_16_2012_03_14
Read Article 16: Loewer,A, Batchelor,E, Gaglia,G, Lahav,G. Basal Dynamics of P53 Reveal Transcriptionally Attenuated Pulses in Cycling Cells, Cell, 142, 89-100, 2010. This is the most recent paper in a long series. Read it to get an overview. Post a PCRC.
Sunday, March 11, 2012
Asgn_17_Class_23_Article_15_2012_03_12
Read Article 15: S. Huang. The molecular and mathematical basis of Waddington's epigenetic landscape: A framework for post-Darwinian biology? BioEssays 34 (2):149-157, 2012.
Read the article and the supplementary material. Post a PCRC.
Read the article and the supplementary material. Post a PCRC.
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