Coupled Organ Chips: Read Article 07 Vernetti, L, et al. Functional Coupling of Human Microphysiology Systems: Intestine, Liver, Kidney Proximal Tubule, Blood-Brain Barrier and Skeletal Muscle. Sci. Rep. 7: 42296. 2017. PMCID: PMC5235976.
Think about how this approach could be used to study the Gut-Liver-Brain axis!
Look at the Del Rio, et al., Nutrients, 2017 to get some idea of how much work was required to confirm the prediction regarding CSF TMAO.
Post a PCRC on the Blog.
The Systems Biology of COVID-19 and the SARS-CoV-2 virus. The class will build a foundation that includes the emergence of complexity, simple biological subsystems, their reductionist and equivalent toy and organ-chip models, and the measurements required to specify model architecture and parameters. Applications to biology, physiology, medicine, chemical and biological defense, pharmacology, drug discovery, and toxicology. UGrad: PHYS 240 01 and BME 290B; Grad: PHYS 326 and BME 395C.
