The Systems Biology of COVID-19 and the SARS-CoV-2 virus. The class will build a foundation that includes the emergence of complexity, simple biological subsystems, their reductionist and equivalent toy and organ-chip models, and the measurements required to specify model architecture and parameters. Applications to biology, physiology, medicine, chemical and biological defense, pharmacology, drug discovery, and toxicology. UGrad: PHYS 240 01 and BME 290B; Grad: PHYS 326 and BME 395C.
Thursday, January 19, 2012
Asgn_6_Class_6_Article_9_2012_01_23
Read Article 9: P. R. LeDuc, W. C. Messner, and J. P. Wikswo. How do control-based approaches enter into biology? Annu.Rev.Biomed.Engr. 13:369-396, 2011. Post a PCRC on the Blog.
Asgn_5_Class_5_Article_8_2012_01_20
Read Article 8: J. P. Wikswo, A. Prokop, F. Baudenbacher, D. Cliffel, B. Csukas, and Momchil. Velkovsky. Engineering challenges of BioNEMS: the integration of microfluidics, and micro- and nanodevices, models, and external control for systems biology. IEE Proc.-Nanobiotechnol. 153 (4):81-101, 2006. Post a PCRC on the Blog.
Tuesday, January 17, 2012
Asgn_4D_Class_4_Article_7_2012_01_18
"Scan Article 7: Vance A. Tucker. The energetic cost of moving about. Sci.Am. 63:413-420, 1975. Be sure to understand Figs. 1-3 and 5, and the concept that energy has to be expended to stretch active muscle."
Asgn_4C_Class_4_Article_6_2012_01_18
Read Article 6: Knut. Schmidt-Nielsen. Organ size and tissue metabolism. In: Scaling: Why is animal size so important?,Anonymous New York:Cambridge University Press, 1984, p. 90-98.. The primary goal is for you to be able to explain the challenges in building multiple, compatible organs on a chip.
Asgn_4B_Class_4_Article_5_2012_01_18
Scan Article 5: Knut Schmidt-Nieldon, Scaling in Biology: The Consequences of Size, J. Expt. Zoology, pp 287-307 (1975). Don't sweat the small details - focus on how scaling works.
Asgn_4A_Class_4_Article_4_2012_01_18
Read Article 4: Wikipedia article on Allometry. Try to gain an understanding of the concept of scaling laws.
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