The Systems Biology of COVID-19 and the SARS-CoV-2 virus. The class will build a foundation that includes the emergence of complexity, simple biological subsystems, their reductionist and equivalent toy and organ-chip models, and the measurements required to specify model architecture and parameters. Applications to biology, physiology, medicine, chemical and biological defense, pharmacology, drug discovery, and toxicology. UGrad: PHYS 240 01 and BME 290B; Grad: PHYS 326 and BME 395C.
Monday, September 26, 2016
SysBio16 Asgn_12B_Class_12_Article_14_2016_10_04
Epigenetics/Attractors: Read Article 14 A.H. Lang, et al., Epigenetic
Landscapes Explain Partially Reprogrammed Cells and Identify Key
Reprogramming Genes PLoS-CB, 10: e1003734 (2014).. This is an actual
implementation of the concept. Post a PCRC.
SysBio16 Asgn_12A_Class_12_Article_13_2016_10_04
Epigenetics/Attractors: Read Article 13 S. Huang. The molecular and
mathematical basis of Waddington's epigenetic landscape: A framework for
post-Darwinian biology? BioEssays 34 (2):149-157, 2012.. Study this
carefully. Post a PCRC
SysBio16 Asgn_11B_Class_11_Article_12_2016_09_29
Epigenetics/Attractors: Read Article 12 S. Huang. Reprogramming cell
fates: reconciling rarity with robustness. BioEssays 31 (5):546-560,
2009.. Study this carefully. Post a PCRC
SysBio16 Asgn_11A_Class_11_Article_11_2016_09_29
Epigenetics/Attractors: Read Article 11 S. Huang, G. Eichler, Y.
Bar-Yam, and D. E. Ingber. Cell fates as high-dimensional attractor
states of a complex gene regulatory network. Phys.Rev.Lett. 94
(12):128701, 2005.. This is an introduction to both cell reprogramming
and data visualization. Post a PCRC.
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