The Systems Biology of COVID-19 and the SARS-CoV-2 virus. The class will build a foundation that includes the emergence of complexity, simple biological subsystems, their reductionist and equivalent toy and organ-chip models, and the measurements required to specify model architecture and parameters. Applications to biology, physiology, medicine, chemical and biological defense, pharmacology, drug discovery, and toxicology. UGrad: PHYS 240 01 and BME 290B; Grad: PHYS 326 and BME 395C.
Tuesday, October 8, 2013
SysBio13 Asgn_11_Class_15_Article_19_2013_10_10
Read Article 19 B. Novak and J. J. Tyson. Design principles of
biochemical oscillators. Nature Rev.Mol.Cell Biol. 9 (12):981-991,
2008. Answer the Pop Quiz before reading, and then read the article to
obtain an overview of the concepts. We will drill down next class. Post
a PCRC.
SysBio13 Pop Quiz - Why Oscillators?
Why do biological systems oscillate, i.e., What is the biological purpose of biological oscillators?
What features of biological oscillators would provide an evolutionary advantage?
What features of biological oscillators would provide an evolutionary advantage?
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