The Systems Biology of COVID-19 and the SARS-CoV-2 virus. The class will build a foundation that includes the emergence of complexity, simple biological subsystems, their reductionist and equivalent toy and organ-chip models, and the measurements required to specify model architecture and parameters. Applications to biology, physiology, medicine, chemical and biological defense, pharmacology, drug discovery, and toxicology. UGrad: PHYS 240 01 and BME 290B; Grad: PHYS 326 and BME 395C.
Brian Evans
ReplyDelete22 / DTRA proposal meeting 3/19
0. Knew: I was somewhat familiar of most of the underlying issues discussed in terms of designing each construct.
1. Learned: That bile collection remains an issue in terms of designing a liver construct. I learned more information on the physiology, biochemistry, and scaling issues associated with the renal system. I also had not given to much thought to how the individual constructs would be integrated into 'megatron' and what metrics would be used to determine organ health/failure.
3. Presentation topic: Considerations for integrating separate tissue constructs into an ex vivo network for pharmacological testing.
4. Thoughts: I was really impressed with the efficiency and intellectual level of the entire meeting. I learned a lot and it was personally gratifying to contribute to a meeting full of experts in their respective fields.
Will Matloff
ReplyDelete22 / DTRA Proposal Meeting 3/19
0. Knew: The contents of DTRA's call and the ideas of the group's proposal.
1. Learned: Some components of the media may not work in the mass spec. The difficulties of keeping the organs separable while allowing them to combine.
2. Pressing?: Does the DTRA call want all of the organs to be easily distributable?
3. Presentation: History and difficulties of cell culture. Automated cell culture systems.
4. Thoughts: I thought the meeting was very good.
Zach Eagleton
ReplyDeleteAssgn_22/Presentation and one page reports review.
0 Knew: the basics of what we had been talking about in class on organ-on-chip.
1 Learned: From what I sat in on, I got a flavor of all the issues we are dealing with, scaling only being one of many.
2 Pressing ?: Are we going to try and oxygenate the system with the lung, and did they modify the LoC design?
3 Presentation: perfluorocarbons as O2 carriers
4 Thoughts: From what I heard from the discussion,seems that there are a vast amount of problems that we have thought about and are going to need solved.