The Systems Biology of COVID-19 and the SARS-CoV-2 virus. The class will build a foundation that includes the emergence of complexity, simple biological subsystems, their reductionist and equivalent toy and organ-chip models, and the measurements required to specify model architecture and parameters. Applications to biology, physiology, medicine, chemical and biological defense, pharmacology, drug discovery, and toxicology. UGrad: PHYS 240 01 and BME 290B; Grad: PHYS 326 and BME 395C.
0. Having dealt with and worked with DARPA in the past I understand their reasoning in the BAAs and am amused by them.
ReplyDelete1. The BAA really hints at a HoC as it wants “ten or more in vitro systems, arranged in any sequence.”
2. I think the most pressing issue that is highlighted in the BAA is that performers must “demonstrate that their constructs reproduce authentic and characteristic responses,” so researchers really need to think about what is available to test and highlight these responses.
3. If multiple OoCs of the same organ were set up what is their variation?
4. Creating and Preventing Strategic Surprise
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ReplyDeleteFrank "Edad" Block, Jr.
ReplyDeleteSysBio13 Asgn_9B_Class_07_DARPA RFP__2013_09_17
0. Knew: Basics of "grantsmanship." IRB procedures.
1. Learned: Use for vaccine testing for biological weapons. Need for IRB review.
2. Pressing: Inclusion of Endocrine as an organ is not defined. At its maximum, it would be VERY complex! Characterizing drug behavior (ADME) on OoC to match in vivo will be a good challenge.
page 29: DARPA discourages such cost strategies.
Is Vanderbilt's DARPA proposal and contract limited to Vanderbilt, or is it a Joint Venture with others?
3. Presentation: How to write a successful grant proposal.
4. Thoughts: Human Subjects Protection: Issue of compensation to persons whose tissue is used for profit!
And what about the Intellectual Property question? What does Vanderbilt have the right to sell or license, vs. what does the government own?
Frank "Edad" Block, Jr.
ReplyDeleteSysBio13 Asgn_9B_Class_07_DARPA RFP__2013_09_17
0. Knew: Basics of "grantsmanship." IRB procedures.
1. Learned: Use for vaccine testing for biological weapons. Need for IRB review.
2. Pressing: Inclusion of Endocrine as an organ is not defined. At its maximum, it would be VERY complex! Characterizing drug behavior (ADME) on OoC to match in vivo will be a good challenge.
page 29: DARPA discourages such cost strategies.
Is Vanderbilt's DARPA proposal and contract limited to Vanderbilt, or is it a Joint Venture with others?
3. Presentation: How to write a successful grant proposal.
4. Thoughts: Human Subjects Protection: Issue of compensation to persons whose tissue is used for profit!
And what about the Intellectual Property question? What does Vanderbilt have the right to sell or license, vs. what does the government own?
SysBio13 Asgn_9B_Class_07_DARPA
ReplyDelete0. Knew: Basic reasoning for why they want a HoC - animal models are proving to have limited relevance or false predictions of response in humans.
1. Learned: How a BAA is outlined/looks like.
2. Questions: In the Platform engineering section, what do they mean by they must "demonstrate sufficient functional or reserve capacity"?
3. Presentation: How collaborations on such a large project are formed.
4. Thoughts: Seems quite demanding (and harsh milestones) considering science never goes as planned/right especially in the anticipated time frame.
0. Knew: The scientific merit of a project is import in order to get funding.
ReplyDelete1. Learned: Potential Contribution and Relevance to the DARPA Mission was the least important factor in getting funding.
2. Questions: what is the timeline that you have set for this project. I would assume that a cost analysis would require a timeline.
3. presentation:
4. Thoughts: Seems straightforward. I do wonder what other projects/ideas were runners up to OoCs for funding
0. Knew: General concept
ReplyDelete1. Learned: All the organs they want included, testing guidelines.
2. Pressing ?:
3. Presentation:
4. Thoughts: I guess it's not surprising that what they are asking for is exactly what we've been talking about.
0 Knew: General requests made by these organizations as outlined in DTRA and NIH call for proposals.
ReplyDelete1 Learned: Government organizations are very interested in OoCs! Their aims are also very high.
2 Pressing: What is the difference between "transformed cells" (p. 6) and cells of human origin? How feasible are these requests for a time frame of 5 years? What is the difference between DTRA and DARPA? are they related at all? requests very similar.
3 Presentation: Qualifications needed to apply for this kind of funding
4 Thoughts: It is interesting to see that everyone is interested in basically the same things! Has technology come far enough to meet demands like this in 5 years? (specifically computer modeling technology)
SysBio13 Asgn_9B_Class_07_DARPA RFP__2013_09_17
ReplyDelete0. Perspectives of OoC as an applicant.
1. The requirements of proposed research of a funding agency.
2. There are many topics we haven’t touched yet, How should we bring up the immune, reproductive and musculoskeletal function of HoC?
3. …
4. This paper helps me understand lots of the origins of the questions we discussed in class.
0. Knew: Systems integration was a goal for OoC.
ReplyDelete1. Learned: DARPA is looking for a rearrangeable platform, to allow organs to be "arranged in any sequence." p.6
2. Pressing ?: Are any labs receiving funding for the optional Disease Model objective? How many awards have been given?
3. Presentation: Successful grant-writing
4.Thoughts: Grant-writing seems fun: a mixture of theoretical science and concrete benchmarks.
0. Knew one function of HoC is to add (hopefully) better results to animal testing
ReplyDelete1. Learned exactly what the government is looking for at what they plan to use this technology for.
2. In the platform engineering section, why do the systems have to be able to be arranged in any sequence? Isn't this supposed to be physiological?
3. Understanding grant proposal requirements
4. This really provides a framework for many of the goals we're trying to achieve.
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ReplyDeleteJPW