The Systems Biology of COVID-19 and the SARS-CoV-2 virus. The class will build a foundation that includes the emergence of complexity, simple biological subsystems, their reductionist and equivalent toy and organ-chip models, and the measurements required to specify model architecture and parameters. Applications to biology, physiology, medicine, chemical and biological defense, pharmacology, drug discovery, and toxicology. UGrad: PHYS 240 01 and BME 290B; Grad: PHYS 326 and BME 395C.
The key of this is that the initial configuration predetermines what will happen in the future. This is like the "Scientific Predestination Model." In this model, we freeze the universe (including all waves and subatomic particles) at a particular point in time (and yes, through the theory of relativity, the particular point in time is determined at one chosen location). Now, if we unfreeze the universe everything will go on a certain course which we can observe as time goes forward. But if we DUPLICATE the entire universe at the exact moment it was frozen, and then unfreeze it, then it will go forward in time in exactly the same way as before. Thus this process includes radioactive decay, Heisenberg uncertainly principle, and everything else that might be seen to introduce "randomness," because we froze the universe with all waves and subatomic particles included. Thus in this model, every thought you have, every action you take, every event that interacts with you, is predetermined by the state of the universe and there is no way that you can change it. "Free will" is thus subservient to the molecules, atoms, subatomic particles, and waves of your body and the external environment. In other words, free will does not exist.
It really makes you visualize how emergent properties can develop. Often we just hear about the pieces and the result/big picture separately, but we miss "seeing" how they are truly connected. Intricacy out of simplicity.
Emergent Phenomena! This is sort of like the cellular-based computing we were discussing. It would be interesting to build a system like this whose hardware (rather than the computer code) drives the interactions and sets the rules for the game.
This helps explain different stages of scientific approach 1. watch the game; 2. set a different initial condition to watch the game/ trial and error to accomplish desired pattern. 3. extract the rules; 4. effectively accomplish the desired pattern.
One thing I noticed from the video is the discussion that you may need many millions of interacting components to produce particular emergent behavior. In cellular automata/agent based systems you can have phase transitions where below a certain threshold the emergent behavior will almost never appear, and above that threshold it almost certainly will (as summarized in Kolmogorov's 0-1 Law http://en.wikipedia.org/wiki/Kolmogorov%27s_zero%E2%80%93one_law).
I wonder if by scaling organs down if you might pass such a critical threshold where there are simply too few cells to produce the organs function.
This model really provides one way that life is not explosive and new generations produces and old generation dies. This model can be also extended to 3-D and hexagon development, which will produces more patterns and implies more life styles. One question is that whether it is applied into cell production if we changes the rules. Another question is that how to build an OoC by applying this idea?
Conway's game of life. God's game of life? It could be that everything we perceive and feel are emergent properties of a complex program which forms our reality. Quantum mechanics could be the result of our studying this simulation at a finer resolution than reality performs at, and reality's counter-intuitive phenomena (bell's inequalities for example) of quantum mechanics are the result of ourselves peeking at, and thus forcing to be computed , phenomena at a finer resolution than the universe's "pixels" of reality.
Conway's game of life. God's game of life? It could be that everything we perceive and feel are emergent properties of a complex program which forms our reality. Quantum mechanics could be the result of our studying this simulation at a finer resolution than reality performs at, and reality's counter-intuitive phenomena (bell's inequalities for example) of quantum mechanics are the result of ourselves peeking at, and thus forcing to be computed , phenomena at a finer resolution than the universe's "pixels" of reality.
Conway's game of life. God's game of life? It could be that everything we perceive and feel are emergent properties of a complex program which forms our reality. Quantum mechanics could be the result of our studying this simulation at a finer resolution than reality performs at, and reality's counter-intuitive phenomena (bell's inequalities for example) of quantum mechanics are the result of ourselves peeking at, and thus forcing to be computed , phenomena at a finer resolution than the universe's "pixels" of reality.
The key of this is that the initial configuration predetermines what will happen in the future. This is like the "Scientific Predestination Model." In this model, we freeze the universe (including all waves and subatomic particles) at a particular point in time (and yes, through the theory of relativity, the particular point in time is determined at one chosen location). Now, if we unfreeze the universe everything will go on a certain course which we can observe as time goes forward. But if we DUPLICATE the entire universe at the exact moment it was frozen, and then unfreeze it, then it will go forward in time in exactly the same way as before. Thus this process includes radioactive decay, Heisenberg uncertainly principle, and everything else that might be seen to introduce "randomness," because we froze the universe with all waves and subatomic particles included. Thus in this model, every thought you have, every action you take, every event that interacts with you, is predetermined by the state of the universe and there is no way that you can change it. "Free will" is thus subservient to the molecules, atoms, subatomic particles, and waves of your body and the external environment. In other words, free will does not exist.
ReplyDeleteAt the least, there will be quantum uncertainty, so the universe will evolve differently.
DeleteCell differentiation can depend upon whether a cell has five or six copies of a transcription regulator moleculne
It really makes you visualize how emergent properties can develop. Often we just hear about the pieces and the result/big picture separately, but we miss "seeing" how they are truly connected. Intricacy out of simplicity.
ReplyDeleteEmergent Phenomena! This is sort of like the cellular-based computing we were discussing. It would be interesting to build a system like this whose hardware (rather than the computer code) drives the interactions and sets the rules for the game.
ReplyDeleteThat is building an OoC!
DeleteThis helps explain different stages of scientific approach
ReplyDelete1. watch the game;
2. set a different initial condition to watch the game/ trial and error to accomplish desired pattern.
3. extract the rules;
4. effectively accomplish the desired pattern.
One thing I noticed from the video is the discussion that you may need many millions of interacting components to produce particular emergent behavior. In cellular automata/agent based systems you can have phase transitions where below a certain threshold the emergent behavior will almost never appear, and above that threshold it almost certainly will (as summarized in Kolmogorov's 0-1 Law http://en.wikipedia.org/wiki/Kolmogorov%27s_zero%E2%80%93one_law).
ReplyDeleteI wonder if by scaling organs down if you might pass such a critical threshold where there are simply too few cells to produce the organs function.
Sorry for the weird spacing... not sure why it's there!
DeleteThis model really provides one way that life is not explosive and new generations produces and old generation dies. This model can be also extended to 3-D and hexagon development, which will produces more patterns and implies more life styles. One question is that whether it is applied into cell production if we changes the rules. Another question is that how to build an OoC by applying this idea?
ReplyDeleteConway's game of life. God's game of life? It could be that everything we perceive and feel are emergent properties of a complex program which forms our reality. Quantum mechanics could be the result of our studying this simulation at a finer resolution than reality performs at, and reality's counter-intuitive phenomena (bell's inequalities for example) of quantum mechanics are the result of ourselves peeking at, and thus forcing to be computed , phenomena at a finer resolution than the universe's "pixels" of reality.
ReplyDeleteConway's game of life. God's game of life? It could be that everything we perceive and feel are emergent properties of a complex program which forms our reality. Quantum mechanics could be the result of our studying this simulation at a finer resolution than reality performs at, and reality's counter-intuitive phenomena (bell's inequalities for example) of quantum mechanics are the result of ourselves peeking at, and thus forcing to be computed , phenomena at a finer resolution than the universe's "pixels" of reality.
ReplyDeleteConway's game of life. God's game of life? It could be that everything we perceive and feel are emergent properties of a complex program which forms our reality. Quantum mechanics could be the result of our studying this simulation at a finer resolution than reality performs at, and reality's counter-intuitive phenomena (bell's inequalities for example) of quantum mechanics are the result of ourselves peeking at, and thus forcing to be computed , phenomena at a finer resolution than the universe's "pixels" of reality.
ReplyDeleteBlog Harvested
ReplyDeleteJPW