Watch TEDx Hamilton Your body in a microchip http://www.youtube.com/watch?v=cn9Q4c3dXGU.
Post a PCRC on the Blog
The Systems Biology of COVID-19 and the SARS-CoV-2 virus. The class will build a foundation that includes the emergence of complexity, simple biological subsystems, their reductionist and equivalent toy and organ-chip models, and the measurements required to specify model architecture and parameters. Applications to biology, physiology, medicine, chemical and biological defense, pharmacology, drug discovery, and toxicology. UGrad: PHYS 240 01 and BME 290B; Grad: PHYS 326 and BME 395C.
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ReplyDelete0. I understood the dynamic of cells and the difference between cells growing in the body and outside of the body.
ReplyDelete1. The architecture of the chip. The potential for applications is seemingly endless however the link between the theory of application to the application is still lacking.
2. What I am unsure about is whether or not the Organ on a Chip is actually mimicking the cells in the body.
3. How to bridge the gap between the theory of OoC to application.
4. I am still new to the concept of the OoC and there are a bunch of possibilities yet there is a lot of in the future comments.
0. Mechanical forces influence cell differentiation and development
ReplyDelete1. Applying mechanical forces to lung cells grown on a membrane results in more natural proliferation, including the formation of cilia.
2. How can we determine how closely the organ on a chip mimics the body? How do we grade it?
3. Standards used to evaluate accuracy of organ on chip models.
4. It seems difficult to replicate an entire organism on a chip. As we have seen, scaling is certainly important. It makes sense to start with a milli human, and gradually work down to micro and nano human models.
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ReplyDeleteDavid Wooten
ReplyDeleteAsgn_2A_Class_02_TEDx Hamilton_2013_08_27
0. Knew: Cells grown in culture react differently to in vivo cells.
1. Learned: An organ on a chip consists of real cells that are "tricked" into believing they are in an organism, through a combination of chemical, mechanical, and electrical controls. It holds the potential to more accurately reflect how cells react to drugs, within the context of a multi-organ system.
2. Pressing ?: How should the separate OoCs be coupled together?
3. Presentation: Comparison between different model systems - cultured cells VS animal VS OoC
4. Thoughts: OoC technology seems quite promising, but this has been my first exposure to it. I was very surprised to learn that just having physical stresses will cause cells to behave differently.
Rui Wang
ReplyDelete0. Knew: a certain system of chip parts can mimic the simple function of certain organs
1. Learned: Different chips can used as a complicated system and applied to test drugs or other purposes.
2. Pressing: Are they are functional in the industrial application currently?
4. The critical limitation of systems on a chip will cause the different reaction in the human body. How to develop a safe system to filter these dangerous signals like opposite results?
Cameron Stewart
ReplyDeleteAsgn_2A_Class_02_TEDx Hamilton_2013_08_27
0. I knew that organs on a chip could be used to better predict the effects of drugs.
1. I learned that realistic mechanical forces on lung cells are important in order for them to react as they would in the body.
2. Philosophical question: Organs on a chip seem to be a more socially acceptable way of making a clone of a person and testing things on them. At what point would an organ on a chip be sufficiently life-like to be entitled to its own rights?
3. Organs on a chip
4. Seems unnecessary to have personalized organs on a chip. I think that rapid DNA sequencing will be available before organs on a chip, and this would be cheaper and sufficient to personalize healthcare. Using the example of a new pharmaceutical drug, I would imagine that correlating the DNA of patients with adverse side effects would demonstrate which genes lead to those side effects. The underlying mechanism of what those genes did would be irrelevant to screening patients for which drugs they should take, assuming that screening them according to their DNA would be effective.
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ReplyDeleteJie Zhao
ReplyDeleteAsgn_2A_Class_02_TEDx Hamilton_2013_08_27
0. the vague idea of Ooc and its potential application in drug testing industry.
1. a. the lung-on-the-chip includes lung cells, and blood vessel cells,
b. the lung-on-the-chip can serve an environment to study white blood cells' immune response towards bacterial and other bio-phenomena;
c. OoC can be used for testing chemical household product;
d. Ooc can make personalized chip for heterogeneous drug reaction;
2. a. Why they add mechanical force control to mimick the situation when human breathe?
is there any evidence that this effect is significant?
3. manufacture of the single layer cell on a chip.
4. a good stretch of mind to think about all the possible application OoC can bring us.
0. I had known about the OoC technology from a seminar given last year in chemical biology and the ability to link different components together
ReplyDelete1. Learned about the mechanic aspects of lung on a chip. I hadn't realized physical forces could be applied to the cells and can see how this would be essential for different systems.
2. Have there been any successful drug discoveries/trials yet? Or is the technology still just too new that we haven't gotten to that point yet?
3. Where OoC technology is currently at and possible applications.
4. Is this the most current update on linking everything together? It seems like the video new, at least the post date, and I'd like to know where exactly the technology is at.
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ReplyDeleteThis comment has been removed by the author.
ReplyDeleteAsgn_2A_Class_02_TEDx Hamilton_2013_08_27
ReplyDelete0. Already Knew: The cost and time limits encountered in drug therapy are becoming even more hindering.
1. Learned: A Vacuum channel is used to create/mimic the pumping/breathing action.
2. Questions: What is the point of the porous membrane between the lung cells and the capillary cells? Is this at all like the real barrier in a human system?
3. Presentation: How to ensure the public does not get the idea that this is at all like a true human. Do not want the public thinking of it like a "clone" if eventually the hope is to use the patient's own cells.
4. The visuals for the chip's build and how it works was very helpful. Much easier to follow for an introduction to OoC than the first papers.
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ReplyDeleteFrank "Edad" Block, Jr.
ReplyDeleteAsgn_2A_Class_02_TEDx Hamilton_2013_08_27
0 Knew: Some of background
1 Learned: Mechanical forces on lung chip. Have YOU on a chip.
2 Pressing: Not going to create a whole human: WHY NOT? Use individual person’s organs to indeed create YOU on a chip. (Cf. Mike Roizen’s “You – The Owner’s Manual”)
3 Presentation: Why not create a whole human? What are the obstacles?
4 Thoughts: Look at global issues and alternate ways to model it (partly computer).
Itamar Shapira
ReplyDeleteAsgn_2A_Class_02_TEDx Hamilton_2013_08_27
0. I realized the usefulness of microfluidics.
1. The ability to have different conditions such as tissue layers exposed both to physiological solution and also air
2. Not sure what the shear is really doing.
3. An overview of OoC
4. Drug development could be expedited using OoC technology.
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