Watch TEDx
Wikswo The Homunculi and I- Lessons from Building Organs on Chips
http://www.youtube.com/watch?v=4ht3m6p8iZ0.
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The Systems Biology of COVID-19 and the SARS-CoV-2 virus. The class will build a foundation that includes the emergence of complexity, simple biological subsystems, their reductionist and equivalent toy and organ-chip models, and the measurements required to specify model architecture and parameters. Applications to biology, physiology, medicine, chemical and biological defense, pharmacology, drug discovery, and toxicology. UGrad: PHYS 240 01 and BME 290B; Grad: PHYS 326 and BME 395C.
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ReplyDelete0. The concept of homanculi was new but the ideas that create the homanculi were somewhat known.
ReplyDelete1. I found the concept of integrating phase space concepts interesting and how that could improve our understanding of the human...we can’t push on a single silo; its a system.
2. I am curious about what the difference
3. What are the effects of micro-fluidic stresses on the cells.
4. The concept was new but I am slowly coming to understand it. I am not a big fan of just saying that gene expression means that the phenotype is being expressed since there are so many modifications that could occur.
0. Homunculi are often used to scale the human form with respect to some variable e.g. mapping the nervous system in terms of nerve density.
ReplyDelete1. OoC's can be thought of as miniature humans, homunculi, and used to observe drug metabolism across multiple organ systems.
2. Don't we lose valuable information by scaling down? There may be cell types that are found at very small concentrations in full-size humans that are impossible to scale to micro or milli size without resulting in fractions of cells.
3. How small is too small.
4. There are many challenges in regulating gene expression and specifying the development of an entire organ. Care must be taken not to oversimplify the system.
David Wooten
ReplyDeleteAsgn_2B_Class_02_TEDx Wikswo__2013_08_27
0. Knew: What an organ on a chip is, how there is an effort to organize them into systems.
1. Learned: A common cause of drug failure is that one organ transforms a drug product into something else, causing problems in another organ.
2. Pressing ?: What is the value of a particular scale homonculus? Would 1/1,000th be good for some things, while 1/1,000,000th is good for others?
3. Presentation: What is the purpose of scaling homonculi?
4. Thoughts: It still seems like an exciting avenue of research. I wonder if larger OoC's would generally give more reliable results than smaller ones.
Rui Wang
ReplyDelete0. Knew: phase space is another way to express the dynamics. It is very important in the classic mechanics because it describes some changes that the normal coordinate x-y can not tell.
1. Learned: Using a combination of expression like gene phase to present organs is programed and easy to be quantified.
2. How to express the network among organs by bringing about each separate gene phase?
4. Is it possible to quantify the development of gene phase of stem cells to that of a certain organ?
Jie Zhao
ReplyDeleteAsgn_2B_Class_02_TEDx Wikswo__2013_08_27
0. the vague idea of Ooc and its potential application in drug testing industry.
1. a. the rationale behind Ooc is that: on petri dish organs don't interact with each other, while in mice, the genes are fundamentally different.
Ooc has the potential to fill this gap.
b. drug is processed in the body in the order of stomach, liver, lung and heart.
c. Dr.brown is Dr. Wikswo's physics-engineering hero in the intelectual phase space.
2. a. what is the longest time span that Ooc can live? considering test the long-term side effects.
3. the long-term culturing of OoC.
4. I think the robustness of Ooc is a key factor, otherwise it'll be difficult to tell the drug effects from the Ooc fluctuation itself.The robustness
test may be very complicated, considering all the types of diseased cell needed to set as a base-line for each specific drug test for specific disease.
0. I had a general idea of what OoC was and a few applications it could be used for.
ReplyDelete1. The ideas of who it would take to make a working chip system is interesting. It will take many people with diverse areas of expertise and interests to complete the project.
2. One of the questions I have is if a self reliant system could be created. For example would the bone on a chip provide the red blood cells for the blood used? Also different organs contain different cell types, is this taken into consideration when constructing the chips?
3. What types of people are needed and the approach taken to make Ooc feasible.
4. So far, it seems like Ooc is a great option. Once developed, the cost would be far less than animal testing and there are really no ethical questions. I would imagine that the results would be more applicable than standard cell cultures.
Asgn_2B_Class_02_TEDx Wikswo__2013_08_27
ReplyDelete0. Knew: The general order of testing - cells in dish, animals, humans.
1. Learned: The term homunculi. Better understood phase space from the talk.
2. Questions: Who are you collaborating with on the mammary gland OoC project? What measurements have been gathered from different OoCs already?
3. Presentation: How the microfluidic chip is created.
4. Thoughts: The way to encourage creativity in society was clever for the audience, but would have liked to have had more emphasis on the OoC details.
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ReplyDeleteFrank "Edad" Block, Jr.
ReplyDeleteAsgn_2B_Class_02_TEDx Wikswo__2013_08_27
0 Knew: General background
1 Learned: Silos and phase space
2 Pressing: Need for wide, wide phase space
3 Presentation: Really looking at the phases that are needed!
4 Thoughts: Love the organ on a chip – also a liver on a potato chip, or a lung on a poker chip
Itamar Shapira
ReplyDeleteAsgn_2B_Class_02_TEDx Wikswo__2013_08_27
0. There is a need for physiologic conditions in tissue engineering research.
1. a. OoC concept; that is, the ability of connected microfluidic systems together to simulate actual phsyiologic systems.
Ooc has the potential to fill this gap.
2. I know we're constructing homunculi... but what if we're constructing homunculi... this seems like creating Frankenstein a little bit..
3. Visualizing phase space (the concept was new to me).
4. This is blurring the boundaries of in vitro/ex vivo/in vivo.
Cameron Stewart
ReplyDeleteAsgn_2B_Class_02_TEDx Wikswo__2013_08_27
0. I already know about organs-on-chips from the other assigned articles.
1. I learned about George Westinghouse who made airbrakes for the railroads and made commercially viable AC current from Niagra falls.
2. Why the huge emphasis on intellectual phase space? I feel like the organs-on-chips stuff is far more interesting and that, by talking about it, it would have been apparent that Prof. Wikswo’s work is interdisciplinary.
3. Topic: About organs-on-chips and that the project is interdisciplinary and requires creative problem solving.
4. I think that a TEDx talk with more emphasis on organs-on-chips and their possible uses would be more interesting and would bring a lot of mainstream attention to the research
Blog Harvested
ReplyDeleteJPW