The Systems Biology of COVID-19 and the SARS-CoV-2 virus. The class will build a foundation that includes the emergence of complexity, simple biological subsystems, their reductionist and equivalent toy and organ-chip models, and the measurements required to specify model architecture and parameters. Applications to biology, physiology, medicine, chemical and biological defense, pharmacology, drug discovery, and toxicology. UGrad: PHYS 240 01 and BME 290B; Grad: PHYS 326 and BME 395C.
Will Matloff
ReplyDelete3C/NIH
0. Knew: Didn't know much about this one except that previous work on living systems on a chip had been done.
1. Learned: NIH is requesting proposals for mico-scale physiological systems. The focus of this RFP is on the biological/tissue engineering side of these systems.
2. Pressing?: What is the best way to achieve population diversity, as they desire?
3. Presentation: Tissue engineering platforms.
4. Thoughts: The example list is ambitious.
Ayeeshik Kole
ReplyDelete3C/NIH
0. Knew: I knew that NIH, along with the other two agencies, put out parallel calls.
1. Learned: The NIH is looking for the integration of multiple organ microsystems, similar to the DARPA call.
2. Pressing?: What is the FDA's role in these calls if they are a partner but not funding any of it?
3. Presentation: Current toxicology methods
4. Thoughts: "It is anticipated that for certain complex organ systems, a single microsystem will not be able to fully capture the functional complexity of the human organ." I thought that line was an important consideration and something the DARPA proposal lacked.
Lucas Hofmeister
ReplyDelete3C/NIH
0. Knew: the general idea
1. Learned: This call emphasizes tissue architecture
2. Pressing: Which system is least studied? It seems like they have to fund at least one of each, so why not pick the one with the least competition? Also, who at the NIH has evaluated the feasibility of integrated systems in the UH3?
3. Presentation: Are drug companies really interested in making drug discovery faster and cheaper
4. Thoughts: It seems like they all but wrote the proposal for us. This is really nice from a grant writing perspective, but it doesn't really open the door for new paradigms or alternative approaches.
Asgn_3C_NIH/Erica Curtis
ReplyDelete0. Knew: I knew that this call had been put out and the basic components about what they were requesting.
1. Learned: The NIH is also looking at the use of stem cells in the constructs.
2. Pressing?: How would you achieve population diversity?
3. Presentation: Online methods of molecular readout.
Zach Eagleton
ReplyDelete3C/NIH
0. Knew: Looking for "organ on a chip" systems
1. Learned: The NIH is willing to accept either human cell lines or stem cells with the latter encouraged
2. Pressing?: what additional challenges are presented when using stem cells vs cultured human cells.
3. Presentation: Current stem cell research
4. Thoughts: This list of organ systems in this proposal is much larger than the other two papers.
Asgn_3C_NIH/WellerEmmons
ReplyDelete0. Knew: That scientists are trying to develop organs on a chip
1. Learned: The NIH thinks stem cells will have contribute to the organ on a chip.
2. Pressing?: Are there any ethical issues developing an organ system from stem cells?
3. Presentation: Pharmaceutical Drug Screening Methods and Technologies
4. Thoughts: If we develop complex systems from stem cells, at which point are we creating life? Will ethical issues arrive from this technology's use of stem cells?
Blog Harvested
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